Female 50 years old endocrine disorders may appear mood irritability, skin changes, gynecological diseases and other symptoms. 1. Emotional irritability: endocrine disorders will make women short-tempered and have greater emotional changes, accompanied by the phenomenon of excessive sweating, and some women will have headaches, emotional tension, irritability, and lack of concentration before menstruation. 2. Skin changes: due to endocrine instability, stimulated by external adverse factors, it will lead to the patient’s skin to appear more yellow spots, pigmentation, facial dullness and other phenomena. 3. Gynecological diseases: endocrine disorders can lead to a series of gynecological diseases in some patients, such as irregular menstruation, dysmenorrhea, abnormal menstrual flow, endometriosis and so on. Endocrine disorders can also manifest as obesity, hair loss, fear of heat, fear of cold, loss of appetite or hyperactivity and other symptoms. If the patient has uncomfortable symptoms, it is recommended that the patient go to the hospital in order to clarify the diagnosis.