The treatment of thickening of large nails needs to be based on the cause of the disease, such as fungal infections caused by the need for antifungal treatment, such as chronic onychomycosis caused by the need for nail removal treatment, etc., such as the congenital thickening of the nails caused by the disease, there is no cure at present, if it affects the function or the emergence of uncomfortable symptoms, you can perform nail extraction. 1. Fungal infections: Fungal infections can cause thickening of the nails, you can use warm water to soak the affected nails, use nail clippers to remove the excess nails in the affected area, and then use medications such as amorphophallus cream to apply localized. At the same time combined with oral antifungal drugs such as terbinafine and other drugs. 2. Chronic onychomycosis: This is caused by local tissue damage and bacterial reproduction when trimming nails. Patients can go to the hospital for nail removal surgery to accelerate wound healing by removing purulent swellings, nail extraction and other operations. 3. Congenital thick nails: mostly related to heredity, there will be thickening of the big toe nails, there is no cure, if there are uncomfortable symptoms or affect the function, you can perform nail extraction. Patients should keep their big toenails clean and dry, wear loose and comfortable shoes, and go to the hospital in time to clarify the cause of the disease and then do targeted treatment. Drugs should be used in accordance with medical advice.