Hand, foot and mouth disease patients with rashes all over their bodies are not necessarily seriously ill. Serious illness is due to the simultaneous combination of myocarditis, meningitis and other infections, the baby’s mental state is extremely poor, high fever persists, and even convulsions and other symptoms can occur. The herpes of the rash is infectious when it breaks, so use a dry cotton swab to absorb the herpes and apply topical acyclovir or ganciclovir ointment for antiviral treatment. Hand, foot and mouth disease is caused by viral infection, most of them can be given symptomatic treatment such as antipyretic fever, and antiviral drugs such as ribavirin or interferon can also be applied. Most of the rashes appear on the day of fever or the second day, and the whole course of the disease is about 7-10 days, with a good prognosis. If symptoms such as extreme depression or even respiratory distress occur, the disease may be severe and requires prompt medical attention.