Severe headache after fever can be treated symptomatically by applying antipyretic and analgesic drugs, such as ibuprofen, acetaminophen, ibuprofen suspension, and lexapro tablets. These drugs can not only cool down the body temperature, but also improve the headache symptoms, while improving the lack of oxygen to the brain. Generally, the symptoms can be gradually improved after applying the drugs. After applying the antipyretic and analgesic drugs, it is necessary to drink plenty of warm boiled water and rest in bed, so as to avoid sweating a lot, which may lead to the body’s defecation. If the elderly have basic cerebrovascular disease, it may induce cerebral infarction and so on, and should pay attention to observe the patient’s condition change. If the headache is not relieved after applying antipyretic and analgesic drugs, and there is nausea, vomiting, or even projectile vomiting, convulsions, and impaired consciousness, etc., it may be the onset of acute cerebrovascular disease or meningitis, meningoencephalitis, or cerebral herniation, etc., which can be life-threatening, and requires immediate medical treatment at the emergency clinic.