For many non-obese young patients with first-onset diabetes, if their blood sugar is high, for example, fasting 12 mmol/L or more, I often advise patients to use insulin as soon as possible to strictly control their blood sugar to near normal levels, preferably for six months or even longer. It may be difficult for many patients to accept this option, but let me give you an example you may understand a little better, for example, a person’s islet cells are like a horse, it is now tired, can’t run and can’t do its work properly, so the patient’s blood sugar starts to rise. At this time do you choose to whip it and let it continue to run until it dies of exhaustion, or do you let it recuperate for a while to regain its strength and then run up for you again? Or do you want to give it more work and let it die quickly? The choice to whip it to keep running until it dies of exhaustion is like using drugs that promote insulin secretion, such as pioglitazone and other drugs are whip drugs, of course, many times whip can make the horse run, but after all, it is holding sick work, right? Recuperate well for a period of time to regain vitality and then run up for you is like using insulin therapy, through exogenous supplementation of insulin, so that your own islet cells get some rest. It is best to let it rest for more than six months, at least three months, so that the horse may still work up properly, which means you still have hope to stop all the drugs pure diet regulation plus proper exercise to control blood sugar. Continue to add to the burden so that it will soon die of exhaustion is like you continue to maintain your high blood sugar state is not well controlled, then the pancreatic islet cells can only hold sick overtime, will not soon die of exhaustion? You should know how important it is to protect the function of the islet cells for diabetic patients. When your own islet function is exhausted and you can only rely on exogenous insulin therapy, your blood sugar control will become very unstable because the regulatory function of your own islet cells is almost lost, and it will be more difficult at that time. I have tried to use plain language to talk about medical reasoning, but the examples may not be entirely appropriate, so patients can also use some medical science articles to learn more about this.