Pancreatic plasma cystadenoma should be operated promptly if there are clinical symptoms or the diameter is larger than 4cm. Pancreatic plasmacytoid cystadenoma is usually benign and often found during physical examination. 1. Surgery is needed if there are clinical symptoms: most of the patients have no obvious symptoms, and some of them have non-specific symptoms, such as abdominal pain and distension, nausea and vomiting, abdominal mass, diarrhea or weight loss, etc. Once the diagnosis is confirmed, surgery should be performed as soon as possible. At this time, once diagnosed, surgery should be carried out as soon as possible. 2. Patients with adenomas larger than 4cm in diameter: pancreatic plasma cystadenomas generally have no malignant tendency, but if the size of adenomas increases to more than 4cm with time, surgery should be considered. For elderly patients with adenomas less than 4cm in diameter, surgical treatment is not recommended and observation is usually the mainstay. Depending on the patient’s specific situation, the treatment plan will also be different, it is recommended to consult a doctor to determine the specific treatment plan.