Thyroid-related ophthalmopathy is one of the most common orbital diseases in adults and is an autoimmune disease, the exact pathogenesis of which is unknown. The basic force of venous return is the pressure difference between the small veins (also known as peripheral veins) and the vena cava or right atrium (also known as central veins). An increase in pressure in the small veins or a decrease in pressure in the vena cava favors venous return. Because of the thin venous walls and low venous pressure, venous return is also influenced by external forces such as muscle contraction, respiratory movements, gravity, etc. When these factors impede venous return, the body will show various manifestations. What are the diseases that are easily confused with orbital venous reflux disorders? 1, myositis type inflammatory pseudotumor Acute onset, pain is obvious, eyelid and conjunctiva congestion and edema are severe, may be accompanied by ptosis, eye movement is limited, hormonal shock or radiation therapy is more obvious. The imaging examination may show irregular enlargement of the extraocular muscles, simultaneous involvement of the muscle belly tendons, and thickening of the ocular ring. 2. Intraorbital tumors A variety of intraorbital tumors can cause protrusion of the eye, and imaging can show round-like or shuttle-shaped occupancy in the orbit, which can be easily confused with thyroid-related eye disease with single muscle hypertrophy. The latter, however, involves both eyes, has typical eyelid signs and is associated with thyroid dysfunction in most patients. In congenital, traumatic, or secondary ptosis of one eye, excessive neural excitation is transmitted to the contralateral healthy eye when looking forward or upward, resulting in recession of the upper lid and an oversized lid fissure without upper lid drop, which needs to be differentiated from thyroid-related eye disease.