Cephalosporins can be used by pregnant women. Cephalosporins are classified into one to four generations. First generation cephalosporins such as cefazolin sodium are better for Gram-positive cocci, with greater hepatic and renal toxicity; second generation cephalosporins such as cefuroxime sodium have more balanced effects on Gram-positive cocci and Gram-negative bacilli, and less hepatic and renal toxicity than the first generation; third generation cephalosporins such as ceftazidime and ceftriaxone have powerful antibacterial activity, stronger on Gram-negative bacilli than Gram-positive cocci, but less effective on anaerobic bacteria; fourth generation cephalosporins such as cefpirome have more powerful anti-infective effects, except for Gram-positive cocci and Gram-negative bacilli. It has strong antibacterial activity against Gram-negative bacilli, but not against anaerobic bacilli; the fourth generation cephalosporins, such as cefpirome, have stronger anti-infection effect, and have certain antibacterial activity against anaerobic bacilli. Cephalosporins should be used with attention to allergic reactions and with caution in some penicillin-positive individuals, as they are classified as Class B drugs by the U.S. Food and Drug Administration for safe maternal use, and can be used safely by pregnant women.