The sour odor of the soles of the feet is considered to be related to inattention to hygiene, hyperhidrosis, tinea pedis and other factors, which can be relieved by changing shoes and socks diligently, antiperspirant and antifungal medicine treatment. 1. Lack of attention to hygiene: If the patient does not pay attention to personal hygiene, wearing shoes or socks for too long, there may be obvious sour odor of the soles of the feet, so change shoes and socks diligently, and give foot soaking treatment. 2. Hyperhidrosis: if the patient has hyperhidrosis, there may be obvious sour smell because of more sweat on the feet, which will be decomposed by bacteria, it can be treated with antiperspirant, such as 5% aluminum acetate solution, 20% aluminum chloride solution, etc. It can also be injected with botulinum toxin locally, which can improve the situation of sweating on the soles of the feet. 3. Tinea pedis: sour odor on the soles of the feet may also be related to tinea pedis factors, after diagnosis, need to cooperate with the doctor to give antifungal treatment, such as miconazole, ketoconazole, econazole, terbinafine, etc., to improve the patient’s symptoms. There are other reasons for the sour odor on the soles of the feet, so if necessary, you need to cooperate with the doctor to improve the examination, and then do processing and treatment.