Among the current treatment options, the traditional Chinese medicine with clear immunosuppressive effect on chronic nephritis is tretinoin tablets, this drug can inhibit the immune activity of T-cells and B-cells, inhibit the production of the corresponding immune factors or complexes, so as to achieve the purpose of treating nephritis. However, it can cause related side effects such as decreased lymphocyte count or decreased protein synthesizing function of the liver, and it can also cause infertility, sterility and other problems. In addition, Cordyceps-related extracts, such as Jinshuibao capsule or huangqi, astragalus, etc. also have a weak effect on reducing urinary protein and improving nephritis.