Elevated creatinine after taking targeted drugs can be relieved by changing dietary habits, controlling drug dosage, renal replacement therapy, etc. In addition, oncologists should be consulted to see if the targeted drugs can be discontinued. 1. Changing dietary habits: patients should control protein intake, as protein intake in excess may cause metabolic burden on the kidneys, and reducing the intake of potassium-containing food can reduce creatinine value to a certain extent. 2. Control the drug dosage: patients should follow the doctor’s instructions when taking targeted drugs, not blindly, you can consult the doctor whether you need to stop. 3. Renal replacement therapy: when the patient’s creatinine rises, and there is oliguria, anuria, can be performed renal replacement therapy. Patients with elevated creatinine after taking targeted drugs are advised to consult regular hospitals and standardize their treatment under the guidance of physicians.