The place where the closed needle is still very painful, mainly because of the following possibilities: First, the site of the closed needle is not grasped correctly, the main indications for playing closed needle is generally pain is more fixed, if it is a wide range of pain, or no clear pain, closed treatment generally can not achieve very good therapeutic results. Second, the pain is more fixed, but not well prepared before playing closed, so that when playing closed not fully give the drug to the lesion, resulting in poorer results after the closure. Third, the concentration of the closed drug is not enough, or the amount is not enough to lead to poor clinical results. Fourth, the use of drugs in excess, the general closed drug is usually limited to 1-2ml, if the use of closed drugs in excess, usually the formation of local tissue edema or swelling, which induces pain.