Patients with high anti-streptococcal hemolysin “O” may suffer from joint pain due to hemolytic streptococcal infection, rheumatoid arthritis and other diseases. 1. Hemolytic streptococcal infection: high anti-streptococcal hemolysin “O” can be seen in patients infected with hemolytic streptococcus caused by tonsillitis, pharyngitis and other diseases, which can also cause patients to experience joint pain symptoms. 2. Rheumatoid arthritis: Rheumatoid arthritis is a reactive disease caused by patients infected with group A beta-hemolytic streptococcus, and patients with this disease often have symptoms such as joint pain and redness and swelling of the joints, so patients with high anti-streptococcal haemolysin “O” and joint pains may be caused by rheumatoid arthritis. Patients with high anti-streptococcal hemolysin “O” may have other reasons for joint pain and soreness, so it is recommended that patients go to the rheumatology and immunology department of regular hospitals, infection departments and other related departments to further clarify the cause of the disease, and standardize the treatment in accordance with the doctor’s instructions.