Usually, traditional minimally invasive pulmonary nodule surgery requires intubation, but with the development of Tubeless VATS (Tubeless Thoracoscopic Surgery) technology, tubeless thoracoscopic minimally invasive pulmonary nodule resection can be performed at this stage. Traditional minimally invasive pulmonary nodule surgery is performed under general anesthesia, requiring tracheal intubation, mechanical ventilation, gastric intubation, urinary intubation, arterial and venous intubation, and drain tube intubation when necessary. The Tubeless procedure minimizes tube irritation to the patient by avoiding tube insertion as much as possible during the perioperative period. Tubeless thoracoscopic minimally invasive pulmonary nodule resection can reduce anesthesia and operation time to a certain extent, reduce redundant incisions, and facilitate postoperative recovery, and its indications are relatively wide, which can be used for wedge resection of pulmonary nodules, alveolar resection, and so on. However, the location and size of lung nodules vary among individuals, so whether tubeless minimally invasive surgery can be performed needs to be evaluated by a physician in conjunction with the patient’s condition. After the appearance of lung nodules, you should go to a regular hospital for examination, make a clear diagnosis, and choose an appropriate surgical method under the guidance of your physician.