Bilateral frontoparietal lobe white matter demyelination is mostly related to infection, degenerative disease, cerebral ischemia and hypoxia and other factors. 1. Infection: Virus, bacteria and other pathogenic microorganisms infection can lead to the destruction of normal myelin in bilateral frontoparietal lobe, so that the patient has bilateral frontoparietal lobe brain white matter demyelination changes. 2. Degenerative lesions: various causes lead to cerebral white matter aging, Alzheimer’s disease and other degenerative changes, it is also easy to make cerebral white matter phospholipid cell apoptosis, so that the patient develops cerebral white matter demyelination lesions. 3. Cerebral ischemia and hypoxia: cerebrovascular diseases lead to ischemia and hypoxia of brain cells, which can easily lead to the destruction of myelophospholipid cells, resulting in demyelination of bilateral frontal lobe white matter of the brain. Bilateral frontal-parietal brain white matter lesions may also be caused by other reasons, please go to the hospital in time, early control of the condition, to prevent deterioration of the condition, and at the same time, avoid trauma, infection and over exertion.