Eye discomfort after applying cosmetics to the eyes is usually caused by the following reasons: 1. Cosmetics accidentally enter the eyes and cause irritation to the cornea and conjunctiva. The corneal and conjunctival tissues are rich in sensory nerve fibers and can be very sensitive to even minor foreign body stimuli. The discomfort caused by cosmetics entering the eye can be relieved by rinsing out the cosmetics with water. 2. This is caused by antibiotic eye drops, for example, tobramycin eye drops.