If one testicle is missing and the other one is functioning normally, it will not lead to osteoporosis. When one testicle is missing, if the function of the other testicle is normal, the hormones secreted by the other testicle can meet the normal demand of the human body, and will not affect the human body, and the physiological activities can be accomplished normally, which will not lead to osteoporosis. However, if one testicle is missing and the function of the other testicle is low, it will lead to the decrease of androgen level in the body, which may lead to osteoporosis. At this time, we should go to the hospital in time to treat the primary diseases, such as varicocele, or supplement androgen to maintain normal physiological needs.