After the mosquito bite blister, on the one hand is the mosquito bite process of detoxification of endotoxins play a role, on the other hand may be the body for foreign body protein allergic rejection reaction. If the blister is not particularly large, then it is recommended to use some external disinfectants to prevent infection, while topical anti-allergy drugs. If the blisters are large and accompanied by generalized fever and malaise, then a serious infection or severe allergic reaction is indicated and anti-infective and anti-inflammatory and anti-allergic medications are needed.