Enterotoxemia in sheep is an acute toxemia caused by toxin production by Clostridium perfringens proliferating in the intestinal tract of sheep. The disease can be acute and cause death in sheep. The kidneys of dead sheep are softened, hence the name “soft kidney disease”. The disease mostly occurs in sheep under 2 years of age with good fat, and sheep are more susceptible than goats. The disease occurs in early summer, and is mainly caused by rain, sudden climate changes, and the consumption of large amounts of grass, concentrate and green fodder, as well as too little exercise. Symptoms Dullness, lying down, gnashing of teeth, falling to the ground in a sideways posture, rolling from side to side, convulsions, head and neck bending, shortness of breath, foaming at the mouth, some sick goats emitting painful moans, and generally dying within 1 to 2 hours of onset. Prevention and treatment The disease should be prevented by vaccinating sheep with the “sheep triple vaccine” in the spring and autumn of each year, and by injecting 5 ml of the sheep vaccine against sheep disease, sheep gonorrhea, intestinal toxemia and sheep dysentery subcutaneously or intramuscularly; strictly controlling the amount of food eaten by sheep; and allowing sheep to exercise moderately every day, especially for captive sheep, which should be driven every day to force them to exercise. Exercise. After the occurrence of enterotoxemia in sheep, if the symptoms are light, use 15-30 ml of ciprofloxacin injection intramuscularly and feed 2 g of streptomycin twice a day for 1 to 2 days.