Headache, fatigue and sore throat are mostly seen in upper respiratory tract infections, which are often caused by viral and bacterial infections. According to the cause and symptoms, you can choose Cotrimoxazole tablets, Pradaxa anti-inflammatory tablets, Amoxicillin capsules and other drugs. 1. Compound aminophenol alkylamine tablets: Headache, fatigue, sore throat, if accompanied by sneezing, runny nose symptoms, may be caused by colds. You can take cold and flu medicines under the guidance of your doctor. If allergic reactions or obvious nausea and vomiting occur after using the medicine, the medicine should be stopped in time. 2. Dandelion anti-inflammatory tablets: Dandelion anti-inflammatory tablets have the effect of clearing away heat and removing toxins, anti-inflammatory and swelling, headache, fatigue and sore throat, which may be related to viral infection caused by the upper respiratory tract infection. Can be taken under the guidance of a doctor, the drug is easy to allergic and have the possibility of causing abortion, allergic people and pregnant women do not take. 3. Amoxicillin capsule: headache and fatigue, as well as the symptoms of sore throat, if the throat is obviously red, swollen, check the blood white blood cell elevation indicates that there is a combination of bacterial infection. Can apply amoxicillin capsules and other antibiotic drugs, because this drug may be allergic, so you should first skin test, not allergic before taking. The symptoms of headache and fatigue as well as sore throat should be examined in a timely manner in the hospital, and standardized treatment should be carried out after clarifying the cause of the disease.