Taking a targeted drug for bone metastasis is getting painful, consider drug resistance and then genetic testing again. Change the treatment regimen if necessary. Taking targeted drugs for bone metastases may lead to a variety of bone injuries and also a variety of bone infections. If this is the case for a long time, care should be taken that the dose of the targeted drug should not be too high. In addition, the therapeutic approach and therapeutic considerations for each targeted drug should be clarified, not too much or too little. However, bone metastasis refers to the hematogenous transfer of malignant tumors to bone tissue. It is commonly seen in breast cancer, lung cancer and other diseases. Common symptoms include pain and fracture. Surgery, radiotherapy, medication and pain management are needed. Although targeted drugs are effective for some people, they are prone to drug resistance, and the treatment effect will be worse in the later stage. Genetic testing is recommended to clarify the treatment effect and change the treatment program if necessary. It is recommended that patients go to the hospital in time to clarify the diagnosis and standardize the treatment.