Platelet 27 is considered severe thrombocytopenia and requires immediate transfusion of fresh platelets, followed by treatment such as dexamethasone, cyclosporine A, and hematopoietic stem cell transplantation, in conjunction with the specific etiology.
Platelets less than 30 × 10⁹ / L for severe thrombocytopenia, belongs to the high-risk, can be accompanied by such as nosebleeds, petechiae, gingival bleeding, and other obvious bleeding tendency, and serious internal bleeding, intracranial hemorrhage is the most common, which can be directly endangered the patient’s life.
If there is bleeding tendency, platelet transfusion is needed to treat, and the cause of thrombocytopenia is identified and treated. The most common causes of thrombocytopenia are as follows:
1. Immune thrombocytopenic purpura: characterized by bleeding from skin mucous membranes and internal organs, thrombocytopenia and so on. Therapeutic intervention is needed if platelets are less than 30 x 10⁹/L, bleeding symptoms, older age, long duration of illness, and coagulation disorders are present. Dexamethasone, gammaglobulin, platelets, rituximab, cyclosporine, etc. may be given.
2. Aplastic anemia: the main manifestations are bleeding, infection, bone marrow hematopoietic hypoplasia, pancytopenia and anemia. Immunosuppressive treatment is effective, such as cyclosporine, and hematopoietic stem cell transplantation can be performed if necessary for severe thrombocytopenia.
3. Pharmacological thrombocytopenia: if it is caused by drugs, it is recommended to reduce the dosage or even stop the drugs when the thrombocytopenia is reduced to <50×10⁹/L. Platelet transfusion can be given in severe cases.
The cause of thrombocytopenia should be and clarified as early as possible, and the primary disease should be actively treated.