The causes of elevated bilirubin mainly include damage to liver cells caused by hepatitis and bile duct obstruction, etc. In addition, physiological factors such as alcohol consumption, staying up all night, and exertion can also lead to the condition, and such people should pay attention to maintaining a healthy lifestyle. Symptomatic treatments, such as phototherapy, splenectomy, antiviral therapy, etc., are needed according to the cause of the disease. 1. Phototherapy: It is applicable to neonatal hyperbilirubinemia. After blue light irradiation, the jaundice of the child can subside and the serum bilirubin can be reduced. 2. Splenectomy: It is suitable for the elevated bilirubin caused by extravascular hemolytic anemia. For example, in hereditary spherocytosis, the spherocytes are easily destroyed when passing through the spleen, and a large amount of unconjugated bilirubin is formed. When the unconjugated bilirubin exceeds the uptake of the hepatocytes, the elevation of blood bilirubin will be caused. Therefore, splenectomy has good efficacy for it. 3. Antiviral therapy: It is suitable for the elevated bilirubin caused by viral hepatitis. In viral hepatitis, the liver cells are damaged and cannot adequately take up the unconjugated bilirubin in the blood, thus causing the elevation of bilirubin. In this case, antiviral treatment with interferon drugs such as pegylated interferon is indicated. Adverse effects such as bleeding, dry mouth, bloating and drowsiness are possible with the use of this drug. There are many other causes of elevated bilirubin. In case of abnormal bilirubin test results, it is recommended to consult a doctor in time to clarify the cause of the disease with the help of the doctor and carry out targeted treatment or therapy.