In most cases of vasculitis, we may apply glucocorticoids for a longer period of time during the treatment process. What are the adverse effects of taking glucocorticosteroids, as follows: First, osteoporosis. Because the glucocorticoids commonly used in clinical practice can inhibit bone formation and promote the occurrence of osteoporosis, we should pay attention to the prevention and treatment of osteoporosis during the treatment process; second, taking hormones can induce and aggravate infections, especially during the use of hormones in larger doses, it has a tendency to increase the risk of infection, such as Mycobacterium, Escherichia coli, fungal infections and herpes zoster Thirdly, glucocorticoids can also induce and aggravate peptic ulcers, so in the process of taking glucocorticoids, we will add some proton pump inhibitors or gastrointestinal mucosal protectors to prevent the appearance of peptic ulcers; fourthly, in the process of taking glucocorticoids in large doses for a long time, we should pay attention to Fourthly, in the process of long-term large dose of glucocorticoids, we should pay attention to the aseptic necrosis of the femoral head, that is, the emergence of femoral head necrosis, and if there is discomfort in the hip joint, we should promptly check the MRI of the hip joint to understand the blood supply of the femoral head; fourthly, some patients may have some mental abnormalities in the process of taking hormones, such as neuroticism, insomnia or emotional abnormalities, or even depression and mania; fifthly, in the process of hormone reduction, we must pay attention to the process of hormone reduction. Fifth, in the process of hormone reduction, we must pay attention to the fact that, especially in patients with hormone reduction, if they have to undergo surgery, or acute trauma or acute infection, acute hyperalgesia may occur under such stressful conditions, in which case we may need to treat them with corticosteroid replacement, and in some patients, we must pay attention to the withdrawal syndrome when reducing the dose, and we must gradually reduce the dose to prevent the disease during the reduction process. In some cases, we must pay attention to the withdrawal syndrome when reducing the dose, and we should gradually reduce the dose to prevent recurrent aggravation of the disease during the reduction process.