D-dimer in late pregnancy does not say that higher than the exact value needs to be treated. It needs to be based on the patient’s VTE (venous thromboembolism) risk factors, clinical symptoms, imaging and D-dimer indicators. D-dimer is a special protein, mainly reflecting the function of fibrinolysis, such as hypercoagulability. The blood of pregnant women in the late stages of pregnancy is physiologically hypercoagulable in preparation for labor and delivery, and D-dimer continues to rise as the pregnancy progresses. Non-pregnant D-dimer levels in the normal range are helpful in ruling out the diagnosis of VTE. However, because D-dimer levels are generally elevated during pregnancy, the value of applying this indicator to rule out VTE during pregnancy and puerperium is very limited. Our study also found that plasma D-dimer levels were higher than normal during pregnancy and early puerperium, suggesting that the current recommended plasma D-dimer reference range (≤0.5 mg/l) for screening VTE in the non-pregnant population is not applicable to pregnant women. D-dimer is not recommended as a screening or diagnostic indicator for maternal VTE, much less as a basis for VTE prevention and treatment based on elevated D-dimer levels alone. However, it is necessary to monitor D-dimer levels during the treatment of patients with clearly diagnosed VTE. Pregnant women need to maintain good living habits, balanced nutrition, avoid exertion and keep a good mood. When discomfort occurs during pregnancy, please go to the hospital in time to avoid delay.