Pale nose color is one of the symptoms of anemia. Anemia is a pathological condition in which the amount of hemoglobin, red blood cell count and red blood cell pressure volume per unit volume of circulating blood is lower than normal. Anemia symptoms are manifested in all organs and systems of the body. Attention should be paid to the rapidity of onset, the progression and the characteristic manifestations. For example, acute aplastic anemia often has a rapid onset and progressive worsening of anemia, while chronic aplastic anemia, iron deficiency anemia, and chronic hemolytic anemia often have a slow onset and course. Acute hemolysis has a rapid onset, with chills and high fever, muscle aches and pains, and may be accompanied by soy sauce-colored urine. Megaloblastic anemia is often associated with inflammation of the mouth and tongue and burning pain. Iron deficiency anemia should be thought of when the anemia is accompanied by heterophilic solution or difficulty in swallowing and pain behind the sternum. Anemia with hemorrhage and fever or infection is most often seen in acute aplastic anemia, leukemia and pernicious histiocytosis. There are many causative factors for anemia, so attention should be focused on asking about bleeding, infection, nutrition, diet and medication. History of exposure to radiation and chemical toxins, pregnancy, childbirth and breastfeeding in women of childbearing age, etc. Bleeding such as peptic ulcer, gastric cancer, hemorrhoids, and heavy menstruation are easily overlooked. Certain groups of people should be aware of hookworm and hemorrhagic infections. Infants, growth spurts, women of childbearing age and the elderly are prone to malnutrition. G6PD deficiency endemic areas should pay attention to the history of taking fresh fava beans and the history of the application of bupropion, sulfonamide, antipyretic and analgesic drugs. History of chloramphenicol, cytotoxic drug application. History of exposure to radiation and toxic chemicals, etc.