Significant pain in the breast and associated pain in the shoulder and back may be due to mastopexy, which is also a sign of referred pain. Mastocytosis is also very common and can occur in adolescent patients due to compensatory enlargement of the mammary glands. It is also very common in middle-aged patients, due to degenerative changes in the breast gland, incomplete rejuvenation, or even nodules or lumps in the breast on examination. Severe pain can be treated with medication. You should pay attention to your daily life and have regular checkups such as color ultrasound or mammography of the breast. Hyperplastic nodules in the breast also have the potential to become malignant, and if necessary, further surgical treatment is required, with partial removal of the breast gland and pathological examination.