Positive anti-SSA antibody in clinical examination is of clinical significance. Strong positivity of anti-SSA antibody is associated with autoimmune liver disease, so liver damage caused by primary biliary cirrhosis, autoimmune hepatitis and other liver diseases can cause positive anti-SSA antibody. Anti-SSA positivity can be seen in a variety of liver diseases such as primary biliary cirrhosis, autoimmune hepatitis, and drug-induced liver damage, as well as in viral hepatitis, and chronic hepatitis C. In addition, anti-SSA positivity is seen in dry syndrome, rheumatoid arthritis, systemic lupus erythematosus, subacute cutaneous lupus, neonatal lupus, and complement C2/C4 deficiency. Therefore, when a patient tests positive for anti-SSA antibodies, it is important to follow the doctor’s instructions for further examination to clarify the cause of the disease.