When it comes to hyperuricemia (HUA), many people are hesitant to talk about it, but when it comes to the “gout” that often accompanies it, many people are “familiar” with it. Most people think that this is just a type of disease that causes pain but is controllable and not life-threatening, but in fact hyperuricemia can cause or aggravate multi-system diseases, especially for cardiovascular disease, which is considered to be an independent risk factor. Conservative estimates suggest that there are 120 million patients with hyperuricemia in China. The diagnosis is made by fasting blood uric acid levels of >420 μmol/L in men and >360 μmol/L in women on two occasions not on the same day on a normal purine diet. It should be emphasized that hyperuricemia is not the same as “gout”, not hyperuricemia must have “gout” symptoms, there are many hyperuricemia without symptoms, which is often overlooked. What are the effects of hyperuricemia on the cardiovascular system? 1, the relationship with hypertension blood uric acid is an independent risk factor for the development of hypertension, clinical research found that 90% of patients with primary hypertension combined with hyperuricemia, secondary hypertension patients only 30% combined with hyperuricemia, the above data and related experiments confirm that hyperuricemia and primary hypertension have a causal relationship. After correcting for the traditional risk factors for hypertension, every 60 μmol/L increase in blood uric acid level increases the relative risk of hypertension by about 13%, and blood uric acid level can predict the occurrence of hypertension. It has been reported that clinical reduction of blood uric acid can reduce the incidence of hypertension, and it has also been reported that reduction of blood uric acid can reduce blood pressure. 2, and the relationship between coronary heart disease 4 large-scale prospective clinical studies (MRFIT, PIUMA, Rotterdam and the United States worksite study) have shown that the level of blood uric acid is a coronary heart disease death of independent risk factors. Some data show that for every 59.5 μmol/L rise in blood uric acid, the risk of death increases by 48% in men and 126% in women, and Bickel et al. found that for patients with clinically established coronary artery disease, blood uric acid is an independent risk factor for all-cause and coronary artery disease death in patients with coronary artery disease. 3, and the relationship between heart failure A Japanese study showed that the prevalence of hyperuricemia in patients with heart failure was 56%, after correcting for a variety of known risk factors affecting the prognosis of heart failure, high uric acid is an independent predictor of all-cause and cardiovascular death, but whether it can be used as a direct or indirect indicator remains to be studied. Small sample clinical studies have also found that lowering blood uric acid levels in patients with heart failure improves the prognosis of heart failure patients. In addition, hyperuricemia can lead to multi-system diseases, such as cerebrovascular disease, endocrine and metabolic diseases, kidney damage, and gout, many of which can indirectly contribute to cardiovascular disease. How to control the blood uric acid level of ordinary people? 1.Healthy diet Usually should be based on a low purine diet, strictly control the intake of meat, seafood, animal offal and other foods, see the table above. 2, drink more water, quit smoking and alcohol Daily water intake to ensure that the urine volume reaches more than 1500ml, advocating smoking cessation, prohibit white wine and beer, red wine can be moderate. 3, adhere to exercise, weight control Daily moderate intensity exercise for more than 30 minutes, weight control in the normal range, that is, height (cm) ÷ weight (kg) square, the value of 18.5-24.9. Most importantly, when the blood uric acid index exceeds the diagnostic index, it is recommended to consult a specialist in time.