The characteristic change in local skin tightening is excessive collagen production and a significant increase in collagen content in the skin. Certain cytokines are involved in the pathogenesis of the disease, such as transforming growth factor, epidermal growth factor, and platelet-derived growth factor. Most patients with scleroderma exhibit Raynaud’s phenomenon, and pathology shows thickened intima, narrowed or occluded lumen of small arteries and microvessels. Local skin tightening: American Rheumatism Association (ARA) 1998 criteria: 1. Primary criteria: Scleroderma changes proximal to the metacarpophalangeal joints, which may involve the entire limb, face, body and drive stem. 2, secondary criteria: ① finger scleroderma: the above skin changes are limited to the fingers. (②Finger tips with depressed scarring and disappearance of finger pads. ③Both lung basal fibrosis. Where 1 major criterion or 2 minor criteria can be diagnosed, other manifestations that contribute to the diagnosis: Raynaud’s phenomenon, polyarthritis or arthralgia, abnormal esophageal motility, dermatopathological collagen fiber swelling and fibrosis, immunological examination of ANA, positive anti-Scl-70 antibody, and attachment site antibody (ACA). CREST syndrome, specifically 3 of the 5 symptoms, or 3 or more of them plus positive mitotic antibodies are diagnostic.