Interstitial pneumonia has been 20 years to symptomatic treatment, combined with psychological treatment at the same time can be considered in conjunction with their own situation for surgical treatment. 1. Anti-fibrosis, if the interstitial pneumonia has been 20 years, still need anti-fibrosis treatment. Combined with the condition and underlying causes, if interstitial fibrosis is secondary to rheumatic immune disease, it is recommended to use glucocorticosteroids such as prednisone and immunosuppressants such as cyclosporine, and for idiopathic interstitial fibrosis, antifibrotic medications such as pirfenidone and nidazanib can be considered. 2. Surgical treatment, for people with long duration of disease and poor effect of conservative treatment, they can consider surgical treatment according to their own conditions, mainly lung transplantation. However, due to the high cost of surgery, and may need to take immunosuppressants for life, so we need to take into account their own situation to decide. It is recommended to seek medical advice from your doctor and take medication as prescribed.