Potassium permanganate should not be used directly on the skin. As a chemical drug, the main purpose of potassium permanganate in clinical practice is to reduce the use of antibiotics by playing a bactericidal role locally, and the most commonly used sites or diseases are perirectal diseases such as hemorrhoids, anal fistula or anal fissure. However, it should be used at a concentration of 1:5000, as light red as possible, and the concentration should not be too high. If the concentration of potassium permanganate is too high, it will cause chemical burns on the skin, which will not only fail to sterilize the skin but also cause great damage to the human skin. Therefore, in clinical practice, potassium permanganate can play a bactericidal role, but must be formulated into a concentration of 1:5000, otherwise it will cause chemical corrosion damage to the skin.