The peeling and flaking on both sides of the nose may be caused by physiological factors or seborrheic dermatitis, which can be solved by choosing skin moisturizing and topical medication according to different reasons. 1. Physiological factors: If the two sides of the nose is only manifested as peeling, no erythema and itchy performance, generally due to simple dry skin caused. At this time, you can use some topical emollients, such as vitamin E cream or use some creams that mimic the human sebaceous membrane. 2. Seborrheic dermatitis: If the sides of the nose in addition to peeling, accompanied by erythema, itching performance, may be due to seborrheic dermatitis caused. Then the patient can be used externally with anti-inflammatory ointment, such as mometasone furoate cream. You can also use ketoconazole cream and other antifungal drugs. When the patient flakes on both sides of the nose, it is recommended to go to the regular hospital for examination in a timely manner, under the guidance of a professional doctor for targeted treatment.