Progesterone injection is mainly injected through intramuscular injection, which can be selected from the gluteus maximus muscle under the guidance of the doctor. Progesterone injection is a progestin drug that can be used to treat menstrual disorders such as functional uterine bleeding, amenorrhea, luteal insufficiency, preeclampsia, habitual abortion, and premenstrual tension syndrome. Generally, progesterone is used by intramuscular injection, and deep intramuscular injection, such as gluteus maximus muscle, should be chosen. When injecting, the site of local skin redness, swelling, hardness and scarring should be avoided, and for patients who have been injected several times, the injection site should be changed constantly to avoid local hardness. In the injection process, need to be taken into the needle quickly, pull out the needle quickly, push the drug slowly, to reduce the pain in the process of injecting drugs. Some patients may experience adverse reactions such as dizziness, nausea, tiredness, tingling, breast swelling, or rash and itching at the injection site during the administration of the drug. For patients with severe liver injury need to contraindicate the use of this drug, kidney disease, hypertension, heart disease edema, need to be careful to use this drug. The use of progesterone should be carried out in accordance with the doctor’s instructions, and any discomfort that occurs during the use of the drug should be treated immediately.