Fever sputum out of the nose may be a cold caused by pneumonia, sinusitis, pharyngolaryngitis, should go to the hospital, the clinical often use medication, depending on the cause of the disease using different drugs for treatment. 1. Pneumonia: Pneumonia leads to the accumulation of a large amount of pus and phlegm, and when coughing, the pus and phlegm may retrograde into the nasopharynx and come out of the nose. Clinically, you need to use penicillin, erythromycin, azithromycin and other antibiotics to treat pneumonia. If the nostrils are blocked, hydroxymetazoline hydrochloride nasal drops can be used. 2. Sinusitis: As the sinuses are infected by bacteria such as Staphylococcus aureus and Streptococcus, a large amount of purulent secretion appears, similar in appearance to pus sputum. Patients can take eucalyptus-pinocampus enteric softgel capsule or Olonma to promote the discharge of sinus secretion. 3. Pharyngolaryngitis: As patients with pharyngolaryngitis may cough, pus and phlegm can easily pass upward from oropharynx to nasopharynx due to sudden change of air pressure, resulting in pus and phlegm coming out from the nose. Patients with pharyngitis can choose budesonide suspension inhalation nebulizer treatment. Patients should be treated with medication under the guidance of a doctor.