Whether uric acid 500 μmol/L requires medication is related to the patient’s own condition. If a patient with uric acid 500 μmol/L does not have a combination of metabolic syndrome such as hyperglycemia and hyperlipidemia, and the patient has no complications such as cardiovascular disease and no gouty arthritis attacks, lifestyle adjustments can be made to help lower blood uric acid. Patients need to adhere to a low purine diet, weight control, drinking plenty of water, and appropriate functional physical exercise. If the patient’s uric acid can be controlled below 420 μmol/L, no medication is needed. However, if the patient has 500 μmol/L uric acid, combined with arthritis and kidney damage, or has already experienced cardiovascular disease, it is necessary to apply uric acid-lowering drugs, and the patient should also pay attention to lifestyle modification.