The vast majority of pain in the middle of the back vertebrae has no clear cause, and may be localized soft tissue injuries, lumbar spine pathology, and involving pain caused by diseases such as pancreatitis. 1. Local soft tissue injury: strain or sprain of the low back, injury to the muscles or ligaments around the spine. It can lead to pain in the middle of the vertebrae. The pain can be acute and sometimes persistent, leading to chronic pain. 2. Lumbar spine lesions: common diseases that cause spinal pain include severe disc herniation, resulting in nerve root compression, pain and discomfort in the affected spinal region, which can lead to pain in the middle of the spine, mostly accompanied by numbness and pain in the lower limbs unilaterally or bilaterally. In addition, degenerative discs cause narrowing of the intervertebral disc space, which compresses the nerves and can also lead to the above symptoms. 3. Other: pain in the middle of the vertebrae may be caused by other diseases, such as pancreatitis, kidney stones, abdominal aortic aneurysm and so on. Poor lifestyle is also a common cause of spinal pain, such as excessive weight lifting, obesity, sedentary lifestyle. Women can also experience spinal pain when pregnant due to increased pressure on the spine and improper posture. There are many causes of pain in the middle of the spine in the back, and it is recommended to maintain a good lifestyle and actively seek medical attention.