It is generally not recommended to take Famotidine together with Omeprazole; both inhibit gastric acid secretion and there is no need to combine them. However, if there is a nocturnal acid breakthrough with the application of a proton pump inhibitor, famotidine can also be added once at bedtime. Famotidine belongs to the H2 receptor antagonist, omeprazole belongs to the proton pump inhibitor, both can inhibit gastric acid secretion, the latter’s effect is better than the former, more not recommended to take together. However, if the proton pump inhibitor alone is not effective and nocturnal acid breakthrough exists, famotidine can be added at bedtime. If you have been taking oral omeprazole for a period of time and the effect is poor it is not recommended to add or change the medication on your own, it is recommended to go directly to the gastroenterology department and adjust the medication according to the doctor’s instructions. At the same time, the drug should be used under the guidance of a physician. Gastrointestinal diseases are greatly influenced by lifestyle habits, and during the medication period, you should pay attention to avoiding spicy and stimulating, too cold and too hot food, eat three meals a day on time, and ensure rest. When discomfort occurs, it is recommended to consult a doctor as soon as possible, under the guidance of a professional physician to standardize the use of medication.