There is no such thing as the “best drug” to kill lung fungus. Fluconazole, voriconazole, and caspofungin are commonly used for fungal infections of the lungs, and should be used according to the patient’s specific condition and in accordance with the doctor’s instructions. Lung fungal infection is a group of clinical symptoms caused by the invasion of fungi into the bronchial tubes, trachea and alveoli, causing inflammatory reactions in their mucous membranes. According to the sputum culture and drug sensitivity test to choose sensitive antifungal drug treatment, so each person has a difference in the applicable drugs, there is no “the best drug”. Lung fungal infections, such as Candida infection, commonly used drugs are fluconazole; Aspergillus infection commonly used drugs are voriconazole, itraconazole; cryptococcal infections commonly used fluconazole, followed by voriconazole or itraconazole can be selected; Pneumocystis infections are preferred to the treatment of sulfamethoxazole tablets, but also can be used to the echinocandins class of antifungal drugs, such as caspofungin, anifungin, and so on. The occurrence of lung fungal infection, should improve the relevant examination, follow the doctor’s prescription medication, not blindly self-medication.