Keratin cyfra21-1 is high with nodules in the lungs, which may be caused by inflammation, lung tumors, lung metastases, and can be treated by drugs and surgery. 1. Inflammatory nodules: Keratin cyfra21-1 slightly high, nodules in the lungs, may be related to local inflammatory infections, if the keratin cyfra21-1 is mildly elevated, you can do CT review of the lungs, to review the test indexes, you can orally anti-inflammatory drugs such as amoxicillin capsule, azithromycin capsule, anti-infective treatment. 2. Lung tumor: Keratin cyfra21-1 exists in the epithelial cytoplasm of lungs and tumors, which is often used to determine lung tumors. If the index is high, and there are nodules in the lungs, which are usually manifested as coughing, coughing up sputum, hemoptysis, etc., lung tumors are usually considered to be treated by surgery, and pathological diagnosis is carried out to determine the benign and malignant nature of lung tumors, and then radiotherapy or chemotherapy will be carried out subsequently. 3. Lung metastases: Keratin cyfra21-1 exists in organs rich in epithelial tissues, such as breast, lung, bladder, intestines and so on. Benign or malignant lesions in these organs will show elevated keratin cyfra21-1, such as nodules in the lungs after lung metastasis of malignant tumors in these organs. Active treatment of the primary focus is needed, combined with radiotherapy and other treatments. Keratin cyfra21-1 is high and there are nodules in the lungs, you should consult a doctor in time to find out the cause of the disease and treat the symptoms.