The presence of leukocytes (++++) in the urine in late pregnancy is recommended to have a clean mid-stream urine culture to clarify the presence of infection. During routine urinalysis in pregnancy, there may be contamination of the vulva that may result in the presence of (++++) white blood cells in the urine. At this point, the patient needs to be further asked if there are any abnormal changes in urination, such as the presence of frequent, urgent or painful urination. If any of these symptoms are present, a possible co-infection is considered and a urine culture is recommended to clarify the infecting organism and select medication for targeted treatment. Whenever possible, cephalosporin antibiotics should be chosen to avoid affecting the fetus, and quinolone antibiotics and macrolide antibiotics should not be used for treatment. However, it is also possible that contamination of the vulva or vagina may lead to urine leukocytes (++++), when the patient usually does not have any conscious symptoms. Patients are advised to take interrupted urine during the retention of urine for culture examination, that is, neither the front end nor the tail end of the urine during a single urination, so as to keep the urine as clean and free from external contamination as possible and to observe the presence of pathogenic bacteria.