Lupus nephritis type IV belongs to a kind of grading standard of lupus nephritis, the higher the grading, the more serious the disease is. Lupus nephritis is an autoimmune disease, which is the result of kidney damage caused by systemic lupus erythematosus. The damage to the kidneys can be graded according to the results of the kidney puncture test. There are 6 grades from type I to type IV, and the higher the grade, the more serious the disease is. Lupus nephritis type IV is diffuse lupus nephritis (involving 50% of the glomeruli), with extensive cell proliferation (endothelial and mesangial cells) and cellular infiltration, and extensive and severe nuclear fragmentation and crumpling. It can be divided into two subtypes, S: segmental lesions (involving <50% of glomerular capillary collaterals) and G: globular lesions (involving ≥50% of glomerular capillary collaterals). Patients with lupus nephritis type IV are recommended to go to regular hospitals for timely consultation and targeted treatment under the guidance of doctors.