A high alkaline phosphatase value of 129 U/L can be caused by physiologic conditions such as bone growth and pathologic conditions such as osteoporosis, hepatitis, and hyperthyroidism. Physiologic conditions require no special treatment, while pathologic conditions such as osteoporosis need to be treated with calcium supplements. 1. Physiological conditions: Alkaline phosphatase can be elevated during bone development, pregnancy or excessive intake of fatty foods. No special treatment is needed. If too much fat-rich food is consumed, a light diet and a reduction in the intake of fatty foods such as meat are needed. 2. Pathologic conditions: (1) Osteoporosis: high alkaline phosphatase due to osteoporosis can be supplemented with calcium-containing diets such as milk, calcium carbonate and other calcium supplements, calcium supplements can have adverse reactions such as belching and constipation, and are contraindicated in patients with hypercalcemia. (2) Hepatitis: Alkaline phosphatase is also elevated in patients with hepatitis. For hepatitis patients need to take different treatment measures for different causes, such as alcoholic hepatitis patients, the main therapeutic measures for alcohol cessation, viral hepatitis patients need to undergo antiviral treatment such as entecavir. The adverse reactions of entecavir include headache, nausea, etc. It is prohibited for those who are allergic to the drug. (3) Hyperparathyroidism: Patients with hyperparathyroidism need to limit the intake of high calcium foods such as milk and fish, and surgery can be used if necessary. The above medications need to be administered in accordance with medical advice. There are many reasons for high alkaline phosphatase value of 129 U/L. If the alkaline phosphatase test result is abnormal, it is recommended to consult a doctor in time to clarify the cause of the disease and to carry out targeted treatment or therapy with the help of the doctor.