Patients with toe pain may be due to extrusion, infection, vascular disease and other factors, as follows: First, extrusion factors: some patients suffer from pain due to long-term extrusion here, such as patients wearing very squeezed shoes for a long time, and standing for a long time, will make the toe area excessive pressure, there will be ischemia, followed by pain symptoms. Second, the infection factor: some patients have pain due to infection here, for example, when the patient cut the nails, cut too short and cause nail infection in the foot, it is very easy to lead to pain in the toe situation. Third, vascular disease: some patients may cause pain due to vascular disease here, such as diabetes patients with long-term poor blood sugar control, often prone to vascular disease in the foot, and the toe ischemia, necrosis, and pain.