11.2.3.1 Gastric cancer Commonly used regimens for chemotherapy: 1. Capecitabine single-agent regimen Chen Qi, Department of Oncology, Mianyang Central Hospital Capecitabine: 850-1250 mg/m2, orally, twice a day, days 1-14; repeated every 3 weeks, total 8 cycles 2. Capecitabine combined with cisplatin (XP) regimen Capecitabine: 1000-1250 mg/m2, orally, twice a day, days 1-14 Cisplatin: 60-80mg/m2, intravenous infusion, day 1; or cisplatin 20mg/(m2?; d), intravenous infusion, day 1-5 Repeat every 3 weeks, total 6-8 cycles 3, fluorouracil combined with cisplatin (FP) regimen Fluorouracil: 425-750mg/m2, intravenous infusion, day 1-5 Cisplatin: 60-80mg/m2, intravenous infusion, day 1-5 /m2, intravenous drip, day 1 (or divided into 2-3 days); or cisplatin: 15-20mg/m2 a day, intravenous drip, days 1-5 Repeat every 3 weeks, total 6-8 cycles 4, capecitabine combined with oxaliplatin (XELOX/CapeOX) Capecitabine: 850-1000mg/m2, oral, twice a day, days 1-14, 7 days interval Oxaliplatin Platinum: 130mg/m2, day 1; or oxaliplatin 65mg/m2, IV, days 1 and 8; repeated every 3 weeks for 6 to 8 cycles 5. Simplified fluorouracil/calcium folinic acid regimen (s calcium folinic acid 5FU2) Calcium folinic acid: 200 to 400mg/m2, IV over 2 hours, days 1 and 2 Fluorouracil: 400mg/m2 a day, IV Then 600mg/m2 a day for 22 hours, day 1 and 2. Repeat every 2 weeks for 8-12 cycles. 6. Oxaliplatin-calcium folinate-fluorouracil regimen (FOLFOX4) Oxaliplatin: 85mg/m2 for 2 hours, day 1; Calcium folinate: 200mg/m2 a day, 2 hours intravenously before fluorouracil, day 1 and 2. Fluorouracil: 400mg/m2 a day, intravenously, followed by 600mg/m2 a day, continuous intravenous drip for 22 hours, day 1 and 2 Repeat every 2 weeks for 8-12 cycles 7. oxaliplatin-calcium folinate-fluorouracil (mFOLFOX6) Oxaliplatin: 85-100mg/m2 a day, intravenous drip for 2 hours, day 1 Folinic acid Calcium: 400mg/m2 a day, IV drip 2 hours before fluorouracil, day 1; Fluorouracil: 400mg/m2 a day, IV drip, then another 2400mg/m2 a day, continuous IV drip 44-48 hours Repeat every 2 weeks for 8-12 cycles 8. Oxaliplatin-calcium folinate-fluorouracil regimen (mFOLFOX7) Oxaliplatin: 85-100mg/m2 intravenously on day 1; Calcium folinate: 200-400mg/m2 a day intravenously 2 hours before fluorouracil on days 1 and 2; Fluorouracil: 2400-3000mg/m2 continuously intravenously for 46 hours Repeated every 2 weeks for 8-12 cycles 9. Epirubicin-cisplatin-fluorouracil regimen (mECF regimen) Epirubicin: 50mg/m2, IV drip, day 1 Cisplatin: 60mg/m2, IV drip, day 1 Fluorouracil: 200mg/m2 a day, continuous IV drip, once a day; or 500-600mg/m2, IV drip for 24h, day 1-5 Repeat every 3 weeks, total 6-8 cycles 10.Capecitabine-Epirubicin-Cisplatin regimen (ECX Capecitabine: 625 mg/m2 once orally twice a day, days 1-14, with 7 days interval Epirubicin: 50 mg/m2 intravenously, day 1 Cisplatin: 60 mg/m2 intravenously, day 1 Repeat every 3 weeks for 6-8 cycles 11.Capecitabine-Epirubicin-Oxaliplatin regimen (EOX) Capecitabine: 625 mg/m2 once orally twice a day, days 1-5 Epirubicin: 50mg/m2, IV, day 1 Oxaliplatin: 130mg/m2, IV, day 1 Repeat every 3 weeks for 6-8 cycles Neoadjuvant chemotherapy should follow the principle of high efficiency and low toxicity, and the chemotherapy regimens to be considered include ECF, or its derivatives ECX, EOX, EOF, or trial Fluorouracil-based agents (including capecitabine) in combination with cisplatin or oxaliplatin, and paclitaxel-based agents such as FOLFOX/ XELOX/XELOPAC. The number of cycles of preoperative chemotherapy is 2 to 4 cycles. Postoperative chemotherapy regimen in combination with radiotherapy 1. 425-600mg/m2 of fluorouracil a day plus 20mg/m2 of calcium folinic acid a day, intravenous drip, day 1-5, repeated once a week 2. 625mg/m2 of capecitabine a time, orally, twice a day, day 1-5 a week during radiotherapy. Palliative chemotherapy for recurrent metastatic gastric cancer Chemotherapy regimen except see all postoperative adjuvant chemotherapy regimens. Others are as follows: 1. Capecitabine-docetaxel (TX) Capecitabine: 825-1000 mg/m2 orally twice a day, days 1-14, intermittently for 7 days Docetaxel: 60-75 mg/m2 intravenously, day 1; repeated every 3 weeks; or 30-36 mg/m2 intravenously, days 1 and 8 repeated every 3 weeks; Caution: Before administration, give 2. Capecitabine-paclitaxel (XELOPAC) Capecitabine: 825-1000mg/m2, orally, twice a day, days 1-14, intermittently for 7 days Paclitaxel: 135-175mg/m2, intravenously, day 1 Repeat every 3 weeks; Caution: Anti-allergic drugs should be given before administration. 3. Docetaxel-cisplatin ( DC) or fluorouracil (DF) Docetaxel: 60-75mg/m2, intravenous infusion, day 1; Cisplatin: 60-75mg/m2, intravenous infusion, day 1 or Fluorouracil: 500-750mg/m2 a day, intravenous infusion, days 1-5 Repeat every 3 weeks; Caution: Give anti-allergic drugs and antiemetic drugs before administration, and pay attention to adequate hydration to prevent renal damage (when cisplatin is used). 4.Docetaxel-cisplatin-fluorouracil (DCF) Docetaxel: 60mg/m2, intravenous infusion for 3 hours, day 1 first Cisplatin: 60mg/m2, intravenous infusion, day 1 Fluorouracil: 500-750mg/m2 a day, intravenous infusion, day 1-5, repeated every 3 weeks; Caution: Anti-allergic drugs should be given before administration; pay attention to the drug’s effect on bone marrow inhibition 5.Paclitaxel-cisplatin-fluorouracil (TCF) Paclitaxel: 135-175mg/m2, intravenous infusion for 3 hours, day 1 first Cisplatin: 60mg/m2, intravenous infusion, day 1 Fluorouracil: 500-750mg/m2 a day, intravenous infusion, day 1-5 Repeat every 3 weeks; Caution: Anti-allergic drugs and antiemetic drugs should be given before administration, and pay attention to Adequate hydration to prevent renal damage 6. Paclitaxel-cisplatin-capecitabine (TCX) Capecitabine: 825-1000mg/m2, orally, twice a day, days 1-14, intermittently for 7 days; Paclitaxel: 135-175mg/m2, intravenous drip for 3 hours, day 1 first; Cisplatin: 60mg/m2, intravenous drip, day 1 Repeat once every 3 weeks; Caution: Anti-allergic drugs and antiemetic drugs were given before administration, and attention was paid to adequate hydration to prevent renal damage 7. Paclitaxel-cisplatin (TC) or fluorouracil (TF) Paclitaxel: 125-175 mg/m2, intravenous infusion, day 1; cisplatin: 60-75 mg/m2, intravenous infusion, day 1 or fluorouracil: 500-750 mg/m2 a day, intravenous infusion, days 1-5 Every 3 Repeat once every 3 weeks; Caution: give antiallergic and antiemetic drugs before administration and pay attention to adequate hydration to prevent renal damage (with cisplatin) 8. Irinotecan-calcium folinic acid-fluorouracil (FOLFIRI) Irinotecan: 150-180 mg/m2, IV infusion over 30-120 minutes, day 1 Calcium folinic acid: 200-400 mg/m2, before fluorouracil IV infusion, days 1 and 2 Fluorouracil: 400mg/m once, IV, then 600mg/m2 continuous IV infusion for 22 hours, days 1 and 2 Repeat every 2 weeks Caution: Observe for delayed diarrhea and acute cholinergic-like reactions. 9, Irinotecan + Cisplatin (IP) Irinotecan: 150-180mg/m2, IV infusion for 0.5-2 hours, day 1 Cisplatin: 60mg/m2, IV infusion, day 1 Caution: pay attention to observation of delayed diarrhea and acute cholinergic-like reactions; pay attention to the effect of drug on bone marrow suppression 10, Tegafur/Uracil-Cisplatin (UFT) regimen: Tegafur/Uracil ( 50mg/112mg per tablet): 3 tablets once, 3 times a day, day 1 to 21 Cisplatin: 60-75mg/m2 intravenously, day 1 Repeat every 3 weeks