Knee pain and numbness may be caused by osteoarthritis, synovitis, meniscus injury and other diseases, need to take medication, surgical treatment for the cause of the disease. 1. Osteoarthritis: knee pain and numbness may be caused by osteoarthritis, patients need to take oral non-steroidal anti-inflammatory drugs under the guidance of a doctor, such as celecoxib, acetaminophen, ibuprofen, etc., or to take arthroscopic cleanup, osteotomy, joint fusion surgery. 2. Synovitis: it may also be caused by synovitis, patients need to take oral non-steroidal anti-inflammatory drugs under the guidance of the doctor, such as ibuprofen, etoricoxib, etc., or local injection of glucocorticosteroid drugs, such as dexamethasone, hydroprednisone, etc., or to take drainage and irrigation, comprehensive treatment of the disease. 3. Meniscus injury: also considered to be caused by meniscus injury, patients can take oral pain medication, such as celecoxib, ibuprofen, etc., or take meniscus suture surgery, meniscoplasty and so on. There are many reasons that lead to numbness and pain in the knee joint when pressed by hand, and it is recommended that patients go to the hospital in time to find out the cause of the disease and then actively take treatment measures.