For the adverse effects of muscarinic drugs, it is mainly the excitatory or inhibitory effect on peripheral nerves. Like the muscarinic drugs themselves also have histamine release, which can lead to hemodynamic changes, resulting in cardiac arrhythmias, lower blood pressure and so on. Others are like non-depolarizing muscarinic drugs like succinylcholine, where hyperkalemia may occur, and hyperkalemia is also a cause of cardiovascular reactions. Then there is the possibility of intragastric pressure, increased intraocular pressure, increased intracranial pressure, like muscarinic drugs can block cholinergic receptors and produce vagal organization, which may cause cardiac arrhythmias. There is also the possibility of sympathetic ganglion depression, and there is also the possibility of phase II block when mixing, which can result in prolonged blockade.