The treatment of headache caused by plateau reaction is mainly handled through the following aspects: First, oxygen absorption, plateau reaction is due to the thin air in the plateau area easily causes brain ischemia and hypoxia, resulting in dizziness and headache, low-flow oxygen absorption helps to improve brain ischemia and hypoxia, relieve dizziness and headache, and improve the body’s tolerance to the hypoxic environment. Second, medication, if persistent headache seriously affects daily life, you can take non-steroidal anti-inflammatory and analgesic drugs, such as ibuprofen extended-release capsules and aminogam tablets, which can help relieve headache symptoms. Thirdly, Chinese physiotherapy, such as acupuncture and acupressure, can promote blood circulation in the head and relax the muscles and bones, which is helpful to relieve headache, pay attention to rest and avoid strenuous activities. If the symptoms are not relieved continuously, the patient can be transferred to a low-altitude area for further treatment.