Patients with atrophic gastritis with enterocolitis do not need long-term medication if cancer has not occurred, but may need long-term medication if cancer has occurred. Atrophic gastritis with enterocolitis and no cancer can follow the doctor’s instructions to use omeprazole, lansoprazole and other acid-suppressing drugs, magnesium alumina carbonate and other gastric mucosal protective agent treatment, accompanied by early satiety, abdominal bloating symptoms can be used to promote gastric dynamics of drugs such as Itopride, some patients with atrophic gastritis are hopeful of reversal of the timely treatment, so there is no need for long-term medication. However, if atrophic gastritis with enterocolitis progresses further and becomes cancerous, surgical resection, chemotherapy, radiotherapy and other treatments will be needed, and long-term medication may be required at this time. When diagnosed with atrophic gastritis with enterocolitis, it is recommended to go to the hospital and consult a professional doctor to determine whether long-term medication is needed in light of the specific situation.