The difference between Si Shen Wan and Gui Su Di Huang Wan is in terms of drug composition, efficacy and main treatment. Si Shen Wan consists of four medicines: nutmeg, tonic oil, schizandra, and Wu Zhu Zi; Gui Fu Di Huang Wan consists of epiphyllum, cinnamon, radix et rhizoma, yam, cornelian cherry, ze diarrhea, poria, and danpi. Si Shen Wan has the effect of warming the kidney and spleen, fixing the intestines and stopping diarrhea; Gui Fu Di Huang Wan has the effect of tonifying the kidney and helping the yang. Si Shen Wan is mainly used for the treatment of symptoms such as diarrhea, loss of appetite, indigestion of food and drink, cold pain in the abdomen and fatigue caused by spleen and kidney yang deficiency (deficiency of yang qi in spleen and kidneys); Gui Fu Di Huang Wan is mainly used for the treatment of cold pain in the lower back and knees, cold pain in the lower abdomen, clear and long or unfavorable urination (unruly urination), impotence, edema and other symptoms caused by kidney yang deficiency. The adverse reactions and contraindications of the above medications are not known. It should be noted that Gui Fu Di Huang Wan should not be taken with indigestible food. It should not be taken by patients with fever and cold. During treatment, abstinence from sexual intercourse is recommended. It is not suitable for people with Yin deficiency and internal heat. The drug should be used under the supervision of a physician to avoid adverse effects.